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ChemicalBook Product Catalog Imiglitazar

1/1

Imiglitazar NEW

$700.00 1mg

$1800.00 5mg

Min. Order
Purity97.33%
Cas No250601-04-8
Supply Ability10g
Update time2024-11-20

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

1YR

United States

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Chemical Properties

Product Name	Imiglitazar
CAS No	250601-04-8
EC-No
Min. Order
Purity	97.33%
Supply Ability	10g
Release date	2024/11/20

Product Introduction

Bioactivity

Name	Imiglitazar
Description	Imiglitazar (TAK559) is a potent PPAR-β/δ receptor agonist with hypoglycemic effects.
In vitro	TAK-559, a partial agonist for hPPARg1, achieves approximately 68% of the maximal activation obtained with rosiglitazone, a known PPARγ agonist. Significant activation of PPARγ is observed at a high concentration (10 μM) of TAK-559. Competition-binding assays using radiolabeled ligand indicate that the transactivation of all hPPAR subtypes by TAK-559 is a result of direct binding of TAK-559 to each subtype. TAK-559 also recruits the coactivator SRC-1 to both hPPARγ1 and hPPARα, and dissociates the corepressor NCoR from both hPPARγ1 and hPPARα[1]. In the presence of 10 μM TAK-559, TNFα- or IL-1β-induced THP-1 cell attachment to cultured endothelial cells is significantly reduced. The secretion of monocyte chemoattractant protein-1 (MCP-1) from endothelial cells is reduced by 36%, accompanied by decreased mRNA expression in the cells. Furthermore, the proliferation and migration of cultured smooth muscle cells are significantly decreased in the presence of TAK-559[3].
In vivo	During TAK-559 treatment, significant elevation of circulating high-density lipoprotein (HDL) cholesterol levels is observed, characterized by an increase in large HDL particles and a decrease in small dense HDL particles. Concurrently, plasma triglyceride and apolipoprotein B-100 levels decrease, while apolipoprotein A-I increases. Hyperinsulinemia and insulin resistance are significantly corrected with the highest dose of 3.0 mg/kg per day in these prediabetic monkeys. Additionally, no adverse effects on representative liver function parameters are observed during the study period[2].
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Keywords	Imiglitazar \| TAK 559 \| TAK559
Inhibitors Related	PHYTOL \| Daidzein \| Gemfibrozil \| Fenofibrate \| Pioglitazone hydrochloride \| 5-Aminosalicylic Acid \| Naringenin \| Fisetin \| 2,3-Butanediol \| Icariin

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