250601-04-8

Imiglitazar (TAK559) is a potent and dual human PPARα and PPARγ1 agonist with EC50 values of 67 and 31 nM.

Imiglitazar (TAK559) is a potent dual agonist of human PPARα and PPARγ1 with EC50 values of 67 and 31 nM.

PPARγ1 31 nM (EC 50 )

PPARα 67 nM (EC 50 )

PPARγ1: 31 nM (EC₅₀); PPARα: 67 nM (EC₅₀)

Store at -20°C

[1] Sakamoto J, et al. A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes. Eur J Pharmacol. 2004 Jul 8;495(1):17-26. DOI:10.1016/j.ejphar.2004.05.020
[2] Seki N, et al. A potent activator of PPARalpha and gamma reduces the vascular cell recruitment and inhibits the intimal thickning in hypercholesterolemic rabbits. Atherosclerosis. 2005 Jan;178(1):1-7. DOI:10.1016/j.atherosclerosis.2004.08.015
[3] Ding SY, et al. A novel peroxisome proliferator--activated receptor alpha/gamma dual agonist ameliorates dyslipidemia and insulin resistance in prediabetic rhesus monkeys. Metabolism. 2007 Oct;56(10):1334-9. DOI:10.1016/j.metabol.2007.05.019