| Name | Hypoxanthine |
| Description | Hypoxanthine (Purin-6-ol), also known as purine-6-ol or Hyp. Hypoxanthine is a naturally occurring purine derivative and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the nucleotide salvage pathway. Under normal circumstances hypoxanthine is readily converted to uric acid.hypoxanthine is first oxidized to xanthine, which is further oxidized to uric acid by xanthine oxidase. |
| In vitro | Hypoxanthine is a naturally occurring purine derivative. It is occasionally found as a constituent of nucleic acids, where it is present in the anticodon of tRNA in the form of its nucleoside inosine. It has a tautomer known as 6-hydroxypurine. Hypoxanthine is a necessary additive in a certain cell, bacteria, and parasite cultures as a substrate and nitrogen source. [1] |
| In vivo | A linear increase of plasma hypoxanthine with duration of hypoxemia is found in pigs, and there is no difference between arterial and venous plasma. There are good correlations between hypoxanthine and lactate, base deficit and pH. Moreover, there is a direct relationship between survival time and an increase in plasma hypoxanthine. Survival time correlates negatively with the rate of hypoxanthine increase (r=-0.62). All animals die when hypoxanthine exceeds 125 pM/liter. The increase of hypoxanthine, thus, reflected the prognosis of acute hypoxia in contrast to base deficit[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : Insoluble
DMSO : 5 mg/mL (36.73 mM), Sonication is recommended.
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| Keywords | Purine nucleoside phosphorylase | Inhibitor | inhibit | Hypoxanthine | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Aceglutamide | L-Pyroglutamic acid | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Formamide | Glycerol | Thymidine | Corn starch | Hyaluronic acid sodium (MW 20 kDa) | Gluconate Calcium |
| Related Compound Libraries | Bioactive Compound Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Natural Product Library | Tobacco Monomer Library | Human Endogenous Metabolite Library | Anti-virus Traditional Chinese Medicine Monomer Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
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