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Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.

White to off-white powder

A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals

ChEBI: A purine nucleobase that consists of purine bearing an oxo substituent at position 6.

Hypoxanthine?is capable of stimulating cell death. It can also induce reactive oxygen species (ROS). It results in endothelial dysfunction via apoptosis, stimulated by oxidative stress.

Crystallise it from hot water and dry it at 105o. [Beilstein 26 II 252, 26 III/IV 2081.]

[1] HELENA BIASIBETTI-BRENDLER. Hypoxanthine Induces Neuroenergetic Impairment and Cell Death in Striatum of Young Adult Wistar Rats.[J]. Molecular Neurobiology, 2018, 55 5: 4098-4106. DOI: 10.1007/s12035-017-0634-z
[2] TIANQIAO YONG . Actions of water extract from Cordyceps militaris in hyperuricemic mice induced by potassium oxonate combined with hypoxanthine[J]. Journal of ethnopharmacology, 2016, 194: Pages 403-411. DOI: 10.1016/j.jep.2016.10.001