1. Materials information
Names
| Name | Hypromellose |
|---|
| Synonym | More Synonyms |
|---|
Hydroxypropyl Methyl Cellulose Biological Activity
| Description | Hypromellose is a water-soluble hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices. |
|---|
| Related Catalog | Signaling Pathways >> Others >> Others Research Areas >> Others |
|---|
| In Vitro | Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect[1]. Hypromellose (hydroxypropylmethylcellulose) has been used in sustained-release pharmaceutical products for many years. When used in matrix tablets, these polymers hydrate on contact with water to produce a viscous gel barrier within and surrounding the tablet. The properties of hypromellose that affect the rate of drug release include the rate of diffusion of water into the dry polymer, the rate of hypromellose hydration and gel formation, the viscosity of the hydrated hypromellose and rate of hypromellose gel erosion[2]. |
|---|
| In Vivo | Punctal occlusion using hypromellose 2% is a low-cost and safe additional treatment for dry eye. Fluorescein and rose bengal staining tests show that there was a significant reduction in signs after occlusion using hypromellose[3]. Hypromellose is effective in improving the blood glucose metabolism and suppressing oxidative stress in mice fed with a high fat diet. The antihyperglycemic and antioxidative effects of hypromellose could be partly attributed to the regulation of hepatic glucose-regulating enzyme activities and activation of the hepatic and erythrocyte antioxidant enzymes. Hypromellose may be useful as biomaterials in the development of functional food or as therapeutic agents against high fat-induced hyperglycemia and oxidative stress[4]. |
|---|
| References | [1]. Li CL, et al. The use of hypromellose in oral drug delivery. J Pharm Pharmacol. 2005 May;57(5):533-46. [2]. Braund R, et al. Hypromellose films for the delivery of growth factors for wound healing. [3]. Capita L, et al. Prospective evaluation of hypromellose 2% for punctal occlusion in patients with dry eye. Cornea. 2015 Feb;34(2):188-92. [4]. Ban SJ, et al. Antihyperglycemic and antioxidative effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in mice fed with a high fat diet. Int J Mol Sci. 2012;13(3):3738-50. |
|---|
Chemical & Physical Properties
| Density | 1.39 |
|---|
| Molecular Formula | C18H38O14 |
|---|
| Molecular Weight | 478.49 |
|---|
| Appearance of Characters | powder |
|---|
| Stability | Stable. Solid is combustible, incompatible with strong oxidizing agents. |
|---|
| Water Solubility | H2O: 50 mg/mL, clear to very faintly turbid, faintly yellow | SOLUBLE |
|---|
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|
| Hazard Codes | Xi |
|---|
| Safety Phrases | 24/25 |
|---|
| RIDADR | NONH for all modes of transport |
|---|
| WGK Germany | 1 |
|---|
| RTECS | NF9125000 |
|---|
. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
For more details, pls contact us freely.
Email address: sun@fdachem.com
Mob: 86 13526505137
WhatsApp/Skype/Wechat/LINE: 8613526505137
China
