Hydroxyecdysone
Modify Date: 2024-01-01 20:42:54
 Hydroxyecdysone structure | Common Name | Hydroxyecdysone |
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| CAS Number | 5289-74-7 | Molecular Weight | 480.634 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 702.1±60.0 °C at 760 mmHg |
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| Molecular Formula | C27H44O7 | Melting Point | 242-244 °C |
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| MSDS | ChineseUSA | Flash Point | 392.4±29.4 °C |
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Use of Hydroxyecdysone
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Cyanotis arachnoides C.B.Clarke which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1].Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. |
Properties
Articles63
Spectrum
Names
| Name | 20-hydroxyecdysone |
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| Synonym | More Synonyms |
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Hydroxyecdysone Biological Activity
| Description | Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Cyanotis arachnoides C.B.Clarke which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1].Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. |
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| Related Catalog | Research Areas >> Cardiovascular Disease Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Autophagy >> Autophagy |
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| References | [1]. Liu H, et al. E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body. Insect Biochem Mol Biol. 2014 Feb;45:30-9. [2]. Phungphong S, et al. 20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats. Steroids. 2017 Oct;126:79-84. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 702.1±60.0 °C at 760 mmHg |
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| Melting Point | 242-244 °C |
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| Molecular Formula | C27H44O7 |
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| Molecular Weight | 480.634 |
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| Flash Point | 392.4±29.4 °C |
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| Exact Mass | 480.308716 |
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| PSA | 138.45000 |
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| LogP | -0.53 |
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| Vapour Pressure | 0.0±5.0 mmHg at 25°C |
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| Index of Refraction | 1.597 |
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| Storage condition | 2-8°C |
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| Water Solubility | alcohol: soluble |
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Toxicological Information
CHEMICAL IDENTIFICATIONCHEMICAL NAME : 5-beta-Cholest-7-en-6-one, 2-beta,3-beta,14,20,22,25-hexahydroxy-, (22R)-
CAS REGISTRY NUMBER : 5289-74-7
MOLECULAR FORMULA : C27-H44-O7
HEALTH HAZARD DATAACUTE TOXICITY DATASPECIES OBSERVED : Rodent - mouse
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 6400 mg/kg
ROUTE OF EXPOSURE : Subcutaneous
SEX/DURATION : male 7 day(s) pre-mating
TYPE OF TEST : Cytogenetic analysis
TYPE OF TEST : Cytogenetic analysis
MUTATION DATADOSE/DURATION : 100 nmol/L
REFERENCE : ENZYAS Enzymologia. (The Hague, Netherlands) V.1-43, 1936-72. Volume(issue)/page/year: 41,183,1971
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 2 |
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| RTECS | FZ8060000 |
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| Packaging Group | II; III |
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| Hazard Class | 4.1 |
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| HS Code | 2937290090 |
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Company Profile
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