| Name | Crustecdysone |
| Description | Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects. |
| In vitro | In C57BL/6J mice fed a high-fat diet, oral administration of 20-Hydroxyecdysone (10 mg/kg/day, for 13 weeks) was able to improve obesity and insulin levels, reducing body weight and body fat content. |
| In vivo | In cells induced by CoCl2, 20-Hydroxyecdysone reduces the production of reactive oxygen species (ROS), diminishes mitochondrial membrane depolarization, and suppresses the release of cytochrome c into the cytoplasm, thereby ameliorating cell damage. In H4IIE cells, 20-Hydroxyecdysone effectively lowers the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), resulting in decreased glucose production. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.16 mM), Sonication is recommended.
DMSO : 55 mg/mL (114.43 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 89 mg/mL (185.17 mM), Sonication is recommended.
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| Keywords | α-Ecdysone | metamorphosis | EndogenousMetabolite | Endogenous Metabolite | ecdysteroid | Ecdysone | ecdysis | Crustecdysone | Caspase | Autophagy | arthropods |
| Inhibitors Related | Sucrose | Stavudine | Cysteamine hydrochloride | Hydroxychloroquine | Daidzein | Ferulic Acid | Paeonol | Glycerol | Thymidine | Naringin | Alginic acid | 3-Indoleacetic acid |
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