Hydrocotyle asiatica extract NEW

The herb has a medicinal history of more than 2000 years in China, and many other countries and regions such as Madagascar, South Africa, India, Southeast Asian countries and South America also use it as a brain medicine, diuretic and adjuvant medicine for leprosy, ulcers and skin diseases. The herb is included in the pharmacopoeia of China, France, Spain, Mexico, India, the Netherlands, Venezuela and other countries. The extract of Centellaasiatica is Centellaasiatica(L.)Urb. Commercial extracts of whole grass are usually standardized to contain 9% snow oxalates. Note: The standard extract specifications of Asiaticoside are: snow oxalic acid 29% ~ 30%, snow asiaticoside 40%, hydroxysnow oxalic acid 29% ~ 30%, and hydroxysnow asiaticoside 1% ~ 2%.

Pharmacological action

1. Anti-ulcer effect of Hydrocotyle asiatica extract can improve the level of gamma-aminobutyric acid (GABA) in the brain of rats with gastric ulcer model, and can also reduce the secretion of gastric acid and the activity of pepsin, showing a good anti-ulcer effect.

2. Enhancing memory effect Hydrocotyle asiatica extract can significantly improve the memory of rats in passive avoidance reaction test.

3. The central nervous system effect of Hydrocotyle asiatica extract has strong central inhibitory effect and cholinoid effect.

4. Antibacterial effect Hydrocotyle asiatica extract has antibacterial and antiviral effects, and has inhibitory effects on Pseudomonas aeruginosa, Proteus and Staphylococcus aureus. In addition, asiaticoside can also dissolve the wax film of bacteria.

5. Stimulating biosynthesis The total triterpene extract of Asiaticum asiaticum can significantly affect cell proliferation and biosynthesis of protein and proteoglycan, and significantly increase collagen and fibrinogen.

6. The effect on skin tissue can accelerate wound healing, promote skin growth, local leukocytosis, connective tissue vascular network hyperplasia, and increase mucus secretion.

7. Other effects Hydrocotyle asiatica extract was given orally to female mice, which showed obvious and long-lasting activity of reducing fertility; Reduced systolic blood pressure and heart rate; Antiviral, anti-tension, anti-stress effects.

Clinical efficacy

Hydrocotyle asiatica extract can be used to treat gastric ulcers, hypertension, skin diseases such as intractable wounds, skin tuberculosis, leprosy, etc. It is mainly used in the treatment of chronic branch, cellular carrier, hepatitis B, mumps, acute jaundice hepatitis, mold of digestive tract, fever, poisoning, nephritis, uremia and other diseases. It is used in India and other countries for brain health, diuresis, leprosy, skin diseases, and as an adjunct treatment for obesity.

Toxic and side effects

In sensitive individuals with contact dermatitis, oral itchiness may occur throughout the body, which can be avoided by intramural injection. May produce a photosensitive reaction. Repeated administration of asiaticoside may be related to skin carcinogens. The median lethal dose of the extract was 1.39g/kg. The subcutaneous injection of asiaticoside in mice and rabbits of 0.04 ~ 0.05g/kg can produce toxic symptoms, and 0.2 ~ 0.25g/kg can increase bleeding time and lead to bleeding. Orally 1g/kg is acceptable to both mice and rabbits.

Application:

It can activate epithelial cells, promote the formation of normal granulation tissue, and inhibit the proliferation of fibrocytes.