| Name | Gossypin |
| Description | Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role in the suppression of inflammation, carcinogenesis, and angiogenesis. |
| In vitro | Gossypin is a flavone extracted from Hibiscus vitifolius, which has been reported to exhibit anti-inflammatory, antioxidant, and anticancer activities.?However, the anticancer properties of gossypin and its molecular mechanism of action against gastric cancer have not been fully investigated.?gossypin is an Aurora kinase A (AURKA) and RSK2 inhibitor that suppresses gastric cancer growth.?Gossypin attenuated anchorage-dependent and anchorage-independent gastric cancer cell growth as well as cell migration.?Based on the results of in vitro screening and cell-based assays, gossypin directly binds to and inhibits AURKA and RSK2 activities and their downstream signaling proteins.?Gossypin decreased S phase and increased G2/M phase cell cycle arrest by reducing the expression of cyclin A2 and cyclin B1 and the phosphorylation of the CDC protein.?Additionally, gossypin also induced intrinsic apoptosis by activating caspases and PARP and increasing the expression of cytochrome c. Gossypin is an AURKA and RSK2 inhibitor that could be useful for treating gastric cancer[2]. |
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 25 mg/mL (52.04 mM)
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| Keywords | Antiinflammatory | inhibit | Nuclear factor-κB | Inhibitor | Antioxidant | Anticancer | cardiovascular,osteoclastogenesis | Antiallergic | NF-κB | Nuclear factor-kappaB | Gossypin | Antiviral | Analgesic |
| Inhibitors Related | Sodium Houttuyfonate | Zingerone | Lidocaine | α-Lipoic Acid | Diethylmaleate | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | 5-Aminosalicylic Acid | Indole-3-carbinol | Diallyl disulfide | Sodium salicylate |
| Related Compound Libraries | Flavonoid Natural Product Library | Pain-Related Compound Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Active Compound Library |
United States
