Property Details
Chemical Name：Gonadorelin Acetate
CAS Number：33515-09-2
Molecular Formula：C₅₅H₇₅N₁₇O₁₃ · xC₂H₄O₂ (x = number of acetate groups)
Molecular Weight：~1182.34 g/mol (free base)
Appearance：White or almost white powder
Solubility Soluble in water, slightly soluble in ethanol
Stability：Stable under recommended storage conditions
Storage Conditions：Store at 2-8°C, protected from light
pH (in solution)：4.0 - 6.0
Mechanism of Action：Binds to gonadotropin-releasing hormone receptors, stimulates LH and FSH release
Therapeutic Uses：- Diagnosis of hypothalamic-pituitary-gonadal axis function
- Treatment of infertility
- Veterinary applications
Administration：Subcutaneous or intravenous injection
Half-life：~10-40 minutes (short-acting)
Metabolism：Rapidly degraded by peptidases in the blood
Toxicity：Low toxicity when used as directed
Precautions;Avoid use in patients with hormone-sensitive conditions
Handling Use appropriate personal protective equipment (PPE) when handling
Gonadorelin Acetate is a synthetic decapeptide analog of the natural gonadotropin-releasing hormone (GnRH). It stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, making it useful in diagnostic and therapeutic applications related to reproductive health.
| Parameter | Specification | Test Result | Method |
|---|
| Appearance | White or off-white powder | Complies | Visual inspection |
| Identification | Complies with reference standard | Complies | HPLC, MS |
| Assay (Purity) | ≥ 98.0% | [Insert Value] | HPLC |
| Water Content | ≤ 6.0% | [Insert Value] | Karl Fischer titration |
| Acetic Acid Content | 5.0% - 8.0% | [Insert Value] | Titration |
| Related Substances | ≤ 2.0% (total impurities) | [Insert Value] | HPLC |
| Heavy Metals | ≤ 10 ppm | [Insert Value] | ICP-MS |
| Residual Solvents | Complies with ICH guidelines | Complies | GC |
| Microbial Limits | Complies with USP <61> | Complies | Microbial testing |
| Endotoxins | < 10 EU/mg | [Insert Value] | LAL test |
| pH (1% solution) | 4.0 - 6.0 | [Insert Value] | pH meter |
| Specific Optical Rotation | [Insert Range] | [Insert Value] | Polarimetry |
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