1. Materials information
Names
| Name | glycocholic acid |
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| Synonym | More Synonyms |
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Glycocholic acid Biological Activity
| Description | Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways. |
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| Related Catalog | Signaling Pathways >> Apoptosis >> Bcl-2 Family Natural Products >> Acids and Aldehydes Research Areas >> Cancer |
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| Target | Human Endogenous Metabolite Bax Bcl-2 MDR1 MRP1 MDR2 |
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| In Vitro | Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways[1]. |
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| References | [1]. Lo YL, et al. Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicin. Eur J Pharm Sci. 2008 Sep 2;35(1-2):52-67. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 655.3±65.0 °C at 760 mmHg |
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| Melting Point | 128°C |
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| Molecular Formula | C26H43NO6 |
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| Molecular Weight | 465.623 |
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| Flash Point | 350.1±34.3 °C |
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| Exact Mass | 465.309052 |
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| PSA | 127.09000 |
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| LogP | 2.45 |
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| Vapour Pressure | 0.0±4.5 mmHg at 25°C |
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| Index of Refraction | 1.645 |
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| Storage condition | Refrigerator |
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| Water Solubility | methanol: 0.1 g/mL, clear, colorless |
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Safety Information
| Hazard Codes | N:Dangerousfortheenvironment; |
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| Risk Phrases | R51/53 |
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| Safety Phrases | S61 |
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| RIDADR | UN 3077 9/PG 3 |
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| WGK Germany | 3 |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
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