| Name | GFB-8438 |
| Description | GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively). |
| Animal Research | Sprague Dawley rats (DOCA-salt rat model of FSGS);30 mg/kg; Administration:s.c.; daily for 3 weeks |
| In vitro | GFB-8438 is a novel TRPC5 inhibitor. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate (PS) in vitro. |
| In vivo | GFB-8438is also efficacious in a hypertensive deoxycorticosterone acetate (DOCA)-salt rat model of FSGS, significantly reducing both total protein and albumin concentrations in urine |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 27.5 mg/mL (71.1 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.17 mM), Sonication is recommended.
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| Keywords | TRPVChannel | TRPV Channel | TRPChannel | TRPC5 | TRP Channel | Transient receptor potential channels | synaptopodin | subtype | selective | rTRPC5 | remodeling | podocytes | mouse | loss | kidney | Inhibitor | inhibit | hTRPC5 | hTRPC4 | GFB-8438 | GFB8438 | GFB 8438 | disease | deoxycorticosterone | cytoskeletal | acetate |
| Inhibitors Related | (+)-Camphor | Fingolimod hydrochloride | Caffeic Acid | Oleoyl Serotonin | (-)-Menthol | Camphor | Pregnenolone | Probenecid | 1,4-Cineole | Capsaicin | trans-Cinnamaldehyde | Methyl salicylate |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |