| Name | Ganoderic acid C2 |
| Description | Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen. Ganoderic acid C2 exhibits high inhibitory activity against the rat lens aldose reductase (IC50 = 3.8 µM). |
| In vitro | The metabolites and pharmacokinetics of Ganoderic acid C2 (GAC2), a bioactive triterpenoid in Ganoderma lucidum in rat plasma were investigated by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Totally, ten minor phase I metabolites of GAC2 were characterized after oral administration of GAC2, on the basis of their mass fragmentation pathways or direct comparison with authentic compounds by high-performance liquid chromatography coupled with diode array detection and electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MS(n)), and liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry (LC-ESI-IT-TOF/MS) methods. Moreover, a rapid and specific method for quantification of GAC2 in rat plasma after oral administration was developed by using a liquid-liquid extraction procedure and HPLC-ESI-MS/MS analysis. |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (96.4 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | Inflammationrelated | Inflammation related | Immunologyrelated | Immunology/Inflammation related | Immunology related | Immunology & Inflammation related | HistamineReceptor | Histamine Receptor | Ganoderic acid C-2 | Ganoderic acid C2 | Ganoderic acid C 2 | Aldose reductase |
| Inhibitors Related | Meclizine dihydrochloride | Mirtazapine | Lidocaine | Famotidine | Epalrestat | Sodium butanoate | Amitriptyline hydrochloride | Alginic acid | Finasteride | Trazodone hydrochloride | Mianserin hydrochloride | Kopexil |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Viral Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Miao medicine Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Anti-virus Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library |
United States
