Gallium(III) oxide NEW

• MOLECULAR FORMULA :

• Ga2-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Intratracheal

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 250 mg/kg

• TOXIC EFFECTS :

• Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)

• REFERENCE :

• GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 9(6),45,1965

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 10 gm/kg

• TOXIC EFFECTS :

• Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal)

• REFERENCE :

• GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(10),13,1980

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 5 gm/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 9(6),45,1965

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Mammal - species unspecified

• DOSE/DURATION :

• 10 gm/kg

• TOXIC EFFECTS :

• Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

• REFERENCE :

• GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(6),58,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **

• TYPE OF TEST :

• TCLo - Lowest published toxic concentration

• ROUTE OF EXPOSURE :

• Inhalation

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 27 mg/m3/2H/4W-I

• TOXIC EFFECTS :

• Lungs, Thorax, or Respiration - changes in lung weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Metabolism (Intermediary) - other proteins

• REFERENCE :

• JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 27,123,1989

• TYPE OF TEST :

• TCLo - Lowest published toxic concentration

• ROUTE OF EXPOSURE :

• Inhalation

• SPECIES OBSERVED :

• Mammal - species unspecified

• DOSE/DURATION :

• 107 mg/m3/4W-I

• TOXIC EFFECTS :

• Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature increase

• REFERENCE :

• GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(6),58,1987

• TYPE OF TEST :

• TCLo - Lowest published toxic concentration

• ROUTE OF EXPOSURE :

• Inhalation

• SPECIES OBSERVED :

• Mammal - species unspecified

• DOSE/DURATION :

• 10100 ug/m3/17W-I

• TOXIC EFFECTS :

• Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in sodium Nutritional and Gross Metabolic - changes in phosphorus

• REFERENCE :

• GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(6),58,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 3 mg/m3 JAN 1993