Name | FX-11 |
Description | FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer. |
In vitro | FX-11 (9 μM, 24-48 h) induces activation of AMP kinase and phosphorylation of acetyl-CoA carboxylase, its substrate. FX-11 disrupts glycolysis and modifies cellular energy metabolism in P493 cells. [1]
FX-11 (0-100 µM, 72 h) impedes cell proliferation in BxPc-3 and MIA PaCa-2 cells. [2] |
In vivo | FX-11 (42 µg/mouse; IP, administered daily for 10-14 days) suppresses P493 tumor growth.[1]
FX-11 (0-2 mg/kg, IP, daily, for 3 weeks) notably retards tumor growth.[2] |
Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 225.0 mg/mL (642.1 mM), Sonication is recommended.
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Keywords | FX 11 | FX11 | FX-11 |
Inhibitors Related | Disulfiram | Methotrexate | ALDH1A3-IN-3 | Rotenone | Mycophenolate Mofetil | Ribavirin | 4-Diethylaminobenzaldehyde | Benzyl alcohol | Isomalt | Isoniazid | Sodium Oxamate | Ivosidenib |
Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |