Basic information Safety Related Supplier

ChemicalBook Product Catalog Biochemical Engineering Amino Acids and proteins Fudosteine

1/1

Fudosteine NEW

$30.00 50mg

$40.00 100mg

$56.00 200mg

Min. Order
Purity99.81%
Cas No13189-98-5
Supply Ability10g
Update time2025-12-03

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP4Y

United States

United States

show more

Enterprise Verified

Business Bank account Basic Contact Infomation Business Address Trade Company

Chemical Properties

Product Name	Fudosteine
CAS No	13189-98-5
EC-No
Min. Order
Purity	99.81%
Supply Ability	10g
Release date	2025/12/03

Product Introduction

Bioactivity

Name	Fudosteine
Description	Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.
In vitro	Fudosteine (FDS), a unique mucolytic antioxidant, shows a stronger scavenging effect of Peroxynitrite than N-acetyl-cysteine on DCDHF oxidation in vitro and in sputum macrophages, and also on Peroxynitrite-induced BSA nitration. Fudosteine (0.1 mM) reduces Peroxynitrite-enhanced interleukin (IL)-1beta-induced IL-8 release and restores corticosteroid sensitivity defected by Peroxynitrite more potently than those induced by H(2)O(2) in A549 airway epithelial cells. [1] Fudosteine significantly inhibits increases in GRO/CINC-1 at 10-100 mg/kg, and neutrophils and goblet cells at 30 and 100 mg/kg. Fudosteine inhibits goblet cell hyperplasia by inhibiting GRO/CINC-1 production and/or neutrophil migration. [2] Fudosteine treatment reduces the expression levels of p-p38 MAPK and p-ERK in vivo and of p-ERK in vitro. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro. [3] Fudosteine significantly suppresses blood flow of tracheal microvasculature increased by SO(2) exposure. Fudosteine scavenges superoxide anion generated from rat neutrophils, and enzymatically generated from xanthine oxidase-acetaldehyde reaction. [4]
In vivo	Fudosteine (500 mg/kg, p.o.) significantly increases the amount of dye excreted into the respiratory tract. Fudosteine increases chloride ion concentration in broncho-alveolar lavage of rats. [5]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O : 10 mM, Sonication is recommended. DMSO : Insoluble
Keywords	mucoactive \| MUC5AC mucin hypersecretion \| MUC5AC \| mRNA \| Inhibitor \| inhibit \| Fudosteine \| derivative \| cysteine
Inhibitors Related	Boc-Lys(Boc)-OH \| (R)-Methyl 2-amino-2-cyclohexylacetate HCl \| Fmoc-Lys(Tfa)-OH \| Aceglutamide \| DL-Proline \| Fmoc-Lys(Z)-OH \| Sodium lauroyl glutamate \| DL-Isoleucine \| Fmoc-Aib-OH \| Fmoc-L-aspartic acid \| H-Glu(OEt)-OEt.HCl \| Fmoc-Lys(Alloc)-OH
Related Compound Libraries	Ferroptosis Compound Library \| FDA-Approved & Pharmacopeia Drug Library \| Bioactive Compound Library \| Approved Drug Library \| Drug-induced Liver Injury (DILI) Compound Library \| ReFRAME Related Library \| Drug Repurposing Compound Library \| Inhibitor Library \| NO PAINS Compound Library \| Orally Active Compound Library \| Bioactive Compounds Library Max \| Human Metabolite Library

show more

Company Profile Introduction

You may like

Recommended supplier

$56.00/200mg

TargetMol Chemicals Inc.

VIP6Y

$5.00/1KG

Wuhan JiyunZen Tech Co., Ltd.

VIP1Y

$30.00/1kg

Henan Bao Enluo International TradeCo.，LTD

$0.00/10mg

Guangzhou PI PI BIOTECH INC

VIP8Y

$8.00/1kg

Hebei baicao biology science and technology co., ltd

$1.00/10g

Guangzhou Biocar Biotechnology Co.,Ltd.

$10.00/1Kg/Bag

Hebei Zhanyao Biotechnology Co. Ltd

$0.00/10g

WUHAN FORTUNA CHEMICAL CO., LTD

VIP5Y

$15.00/1KG

Zhuozhou Wenxi import and Export Co., Ltd

$0.00/1KG

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

MSDS|CAS|CAS DataBase|Pricacy|Terms|About Us|New Products| Contact us|Computer Version
Chemical Book