5-Fluorouracil is a potent antineoplastic agent that affects pyrimidine synthesis by depleting intracellular dTTP by inhibiting thymidylate synthase。
5-Fluorouracil is mainly applicable to colorectal cancer, gastric cancer, breast cancer, squamous cell carcinoma of the head and neck, etc. It mainly plays an anti-tumor effect by inhibiting the synthesis of DNA and RNA, leading to apoptosis.
Density 1.7±0.1 g/cm3
Boiling point 401.4±48.0 °C at 760 mmHg
Melting point 282-286 °C (dec.)(lit.)
Molecular formula C4H3FN2O2
Molecular weight 130.077
Flash point 196.5±29.6 °C
Exact mass 130.017853
PSA 65.72000
LogP-2.10
Appearance white to almost white crystalline powder
Vapor pressure 0.0±1.0 mmHg at 25°C
Refractive index 1.596
Storage conditions
This product should be sealed and kept dry.
Stability Stable. Light sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases.
Water solubility 12.2 g/L 20 ºC