Treatment of prostatic hyperplasia finasteride is a basic drug in the treatment of prostatic hyperplasia and prostatitis in China. It is a synthetic 4-nitrogen steroid hormone compound, a resistant hormone drug, which can selectively inhibit 5α - reductase, make the conversion of testosterone into 5α - dihydrotestosterone (DHT) process, and reduce the level of male hormone in prostate cells. Serum prostate-specific antigen decreased, enlarged prostate volume decreased, urine flow rate increased, thereby reducing the symptoms of patients, to achieve the purpose of treating prostate hyperplasia. The action of the drug is characterized by the selective blocking of androgen stimulation of the prostate gland, but it rarely affects the sexual function of men. Prostatic hyperplasia, also known as hypertrophy of the prostate, causes compression of the bladder neck and posterior urethra, causing urinary tract obstruction and other symptoms and complications, making patients deeply painful, mostly in men over the age of 50. The treatment of male hair loss drug Chemicalbook finasteride is also a specific inhibitor of 5α-reductase, which belongs to the class of resistant hormones. It can prevent the conversion of testosterone into DHT, thus reducing the synthesis of DHT, reducing the content of DHT in scalp hair follicles and serum, and restoring the hair growth function of the hair follicle papilla that has been suppressed. To promote hair growth and prevent continued hair loss, finasteride is currently the only oral drug approved by the U.S. Food and Drug Administration for the treatment of male pattern hair loss, with a recommended dose of 1mg once. Chemical properties White or white like crystalline solid. Soluble in chloroform, dimethyl sulfoxide, ethanol, methanol or n-propanol, insoluble in propylene glycol or polyethylene glycol 400, very slightly soluble in 0.1mol/L hydrochloric acid, 0.1mol/L sodium hydroxide solution or water. Melting point about 257℃; There is also a melting point of 252 ~ 254℃. [α]D-59°(C=l, methanol).
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