| Name | Fenbufen |
| Description | Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation. |
| In vivo | Fenbufen and its metabolites could be involved in mitochondrial toxicity through inhibition of ATP synthesis[1]. Fenbufen inhibited prostaglandin release by 80% and reduced rates of protein synthesis in normal muscle and in muscle undergoing hypertrophy in response to tenotomy of a synergist[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+90% Corn oil : 10 mg/mL (39.33 mM), Solution.
Ethanol : 47 mg/mL (184.84 mM), Sonication is recommended.
DMSO : 250 mg/mL (983.17 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : < 10 mg/mL (39.33 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
10% DMSO+90% (20% SBE-β-CD in Saline) : < 10 mg/mL (39.33 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
H2O : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+90% Corn Oil : 2 mg/mL (7.87 mM), Sonication is recommended.
10% DMSO+90% Saline : < 10 mg/mL (39.33 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
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| Keywords | tendinitis | osteoarthritis | Inhibitor | inhibit | Fenbufen | Cyclooxygenase | COX | CL82204 | CL 82204 | Caspase | ATP systhesis | antirheumatic | antipyretic | anti-inflammatory | ankylosing spondylitis | analgetic |
| Inhibitors Related | Naproxen sodium | Acetaminophen | Phenidone | Gallic Acid Monohydrate | Magnesium acetate tetrahydrate | Cystamine dihydrochloride | Copper Sulfate Pentahydrate | Indomethacin | Paradol | Trometamol | 5-Methylfurfural | Magnesium sulfate |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Protease Inhibitor Library | Drug Repurposing Compound Library | Drug-Fragment Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
