Basic information Safety Related Supplier

ChemicalBook Product Catalog Chemical Reagents Organic reagents Hydrazone FCCP

1/1

FCCP NEW

$32.00 5mg

$46.00 10mg

$83.00 25mg

Min. Order
Purity99.65%
Cas No370-86-5
Supply Ability10g
Update time2026-03-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

show more

Enterprise Verified

Business Bank account Basic Contact Infomation Business Address Trade Company

Chemical Properties

Product Name	FCCP
CAS No	370-86-5
EC-No
Min. Order
Purity	99.65%
Supply Ability	10g
Release date	2026/03/13

Product Introduction

Bioactivity

Name	FCCP
Description	FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer.
Cell Research	Protein synthesis rate is assayed in 24-mm diameter multi-well dishes with fresh medium containing 0.175 Ci/mmol of [3H]methionine (200 μM), for 30 min at 37°C. PC12 cells are treated with FCCP for different period of times. (Only for Reference)
In vitro	METHODS: Rat ventricular myocytes were treated with FCCP (10-1000 nM) for 1400 sec, and cellular oxygen consumption was measured using a Clark Oxygen Electrode. RESULTS: Oxygen consumption increased significantly, immediately, and in a dose-dependent manner after the addition of FCCP. [1] METHODS: Rat adrenal medullary chromaffinoma cells PC12 were treated with FCCP (30 µM) for 0.5-2 h. The rate of protein synthesis was measured using [3H]methionine. RESULTS: FCCP treatment produced a strong inhibition (68%) of protein synthesis rate for at least 2 hours. [2]
In vivo	METHODS: To test the effect on stroke, FCCP (1 mg/kg) was injected intraperitoneally into a C57BL/6J mouse model of stroke, followed by one hour of transient middle cerebral artery occlusion (tMCAO). RESULTS: Infarct volumes in the cortex, striatum, and whole hemisphere were significantly increased in mice pretreated with FCCP. Mice receiving FCCP had significantly increased neurologic deficit scores compared to carriers. [3] METHODS: To assay anti-tumor activity in vivo, FCCP (1 mg/kg) and cisplatin (2 mg/kg) were intraperitoneally injected every two days for two weeks into C57BL/6 mice harboring mouse ovarian epithelial carcinoma tumor ID8. RESULTS: The combination of FCCP and cisplatin inhibited tumor growth via OMA1-induced mitochondrial and ER stress. [4]
Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.55 mg/mL (10.03 mM), Solution. DMSO : 55 mg/mL (216.39 mM), Sonication is recommended.
Keywords	MitochondrialMetabolism \| Mitochondrial Metabolism \| Inhibitor \| inhibit \| FCCP \| ATPase
Inhibitors Related	Ciprofloxacin hydrochloride monohydrate \| 1-Hexanol \| Phenoxyethanol \| Imeglimin hydrochloride \| Rotenone \| Sodium oleate \| (-)-Epigallocatechin Gallate \| Sodium Molybdate \| 4-Pentenoic acid \| Revaprazan hydrochloride \| 4'-Hydroxychalcone \| L-Histidine
Related Compound Libraries	PI3K-AKT-mTOR Compound Library \| Cuproptosis Compound Library \| Glycometabolism Compound Library \| Target-Focused Phenotypic Screening Library \| Mitochondrial Membrane Protein-Targeted Compound Library \| Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| ReFRAME Related Library \| Mitochondria-Targeted Compound Library \| Immunology/Inflammation Compound Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max

show more

Company Profile Introduction

Citations

You may like

Recommended supplier

Send Inquriy