Ethyl 4-(4-Fluorophenyl)-2,4-Dioxobutanoate CAS 31686-94-9 | Leading Supplier of High-Activity Fluorinated Ester Intermediates
[Core Keywords]: Ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate supplier, CAS 31686-94-9, fluorinated ester pharmaceutical intermediates, agrochemical synthetic building blocks
Basic Product Information
Chemical Name: Ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate
CAS No.: 31686-94-9 (Title-level keyword optimization)
Molecular Formula: C₁₂H₁₁FO₄
Appearance: Colorless to light-yellow oily liquid
Purity: ≥98.0% (HPLC, pharmaceutical intermediate grade)
Key Physicochemical Properties (Structured data optimization)
| Attribute | Value |
|---|
| Molecular Weight | 238.21 g/mol |
| Boiling Point (0.5 mmHg) | 185–188℃ |
| Density (25℃) | 1.24 g/cm³ |
| Refractive Index (n²⁰/D) | 1.522–1.526 |
| Solubility | Soluble in acetone, DCM; slightly soluble in ethanol; insoluble in water |
| Flash Point (closed cup) | 132℃ |
| Storage Conditions | Light-protected, sealed, 2–8℃ |
Upstream/Downstream Industrial Chain Integration
▶ Upstream Raw Material Assurance
Core Intermediates: 4-Fluorobenzoyl acetic acid, ethyl chloroformate
Process Optimization: Low-temperature esterification condensation technology (Yield >92%, impurities <0.5%)
▶ Downstream Application Expansion
Antineoplastic Drugs: Kinase inhibitor side-chain synthesis
Agrochemical Fungicides: Precursors for methoxyacrylate compounds
Functional Materials: LCD intermediate for display materials
Photoinitiators: Active monomer for UV-curable coatings
Industry Solutions & Technical Advantages
| Application Field | Typical Scenario | Technical Advantages |
|---|
| Anticancer Drugs | EGFR-TKI drug-resistant mutant inhibitor R&D | Fluorine electronic effect for >95% selectivity control |
| Agrochemicals | Novel HPPD inhibitor molecular scaffold modification | Hydrolysis resistance (pH 5–9 stability >90%) |
| Optoelectronic Materials | Organic semiconductor hole transport layer fabrication | Purity ≥99.9% (molecular distillation purification) |
| Polymer Materials | Polyester modification toughening agent synthesis | Ester ring-opening reaction yield >93% |
SEO Keyword Matrix
Core Keywords:
"Ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate price"
"CAS 31686-94-9 technical specifications"
"High-activity fluorinated ester supplier"
Long-Tail Keyword Combinations:
"Custom kinase inhibitor intermediate production"
"UV-curable material raw material supplier"
"REACH pre-registered 31686-94-9 manufacturer"
Compliance Declarations
✅ EINECS Status: Not listed (Based on ECHA database search)
✅ REACH Progress: PPORD exemption application in progress (R&D compliance)
✅ EU Export: Joint registration support (Simplified process for annual export <1 ton)
✅ Analysis Reports: Full documentation (HPLC, ¹H NMR, ¹⁹F NMR) provided
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