| Name | DOV-216,303 Free Base |
| Description | DOV-216,303 Free Base (DOV-216303) is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects. |
| In vivo | In male Sprague Dawley rats of OBX or Sham surgery, DOV 216,303 (20 mg/kg; i.p.; choronic) increases extracellular concentrations of dopamine, norepinephrine and serotonin and significantly increases extracellular baseline serotonin concentrations while DOV-216,303 (20 mg/kg; i.p.; acute) significantly increases dopamine, norepinephrine and serotonin levels[2]. |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 125 mg/mL (547.96 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (17.53 mM), Sonication is recommended. Ethanol : 95 mg/mL (416.45 mM), Sonication is recommended.
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| Keywords | SLC6A3 | SerotoninTransporter | Serotonin Transporter | serotonin | norepinephrine | Norepinephrine | DOV216303 | DOV-216,303 Free Base | DOV216,303 Free Base | DOV-216,303 | DOV 216303 | DOV 216,303 Free Base | DopamineReceptor | Dopamine Transporter | Dopamine Receptor | dopamine | Dopamine | DAT |
| Inhibitors Related | Dapoxetine hydrochloride | Clozapine N-Oxide | Mirtazapine | Diosmin | Octopamine hydrochloride | Citicoline | Amitriptyline hydrochloride | Oxolinic acid | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine | Fluphenazine dihydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Antidepressant Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library |