ChemicalBook CAS DataBase List 66504-40-3

66504-40-3

Name	1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
CAS	66504-40-3
Molecular Formula	11H11Cl2N
MDL Number	MFCD22381599
Molecular Weight	228.118
MOL File	66504-40-3.mol

Chemical Properties

Boiling point	324.4±37.0 °C(Predicted)
density	1.371
storage temp.	Store at -20°C
solubility	DMSO : ≥ 125 mg/mL (547.96 mM);Water : < 0.1 mg/mL (insoluble)
form	Oil
pka	10.45±0.40(Predicted)
color	Colorless to light yellow

Hazard Information

Uses

DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively[1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[2].

in vivo

Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals^[2].
Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations^[2].

Animal Model:	Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery^[2].
Dosage:	20 mg/kg.
Administration:	I.P. daily for 17days.
Result:	Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations.

Animal Model:	Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery^[2].
Dosage:	20 mg/kg.
Administration:	I.P. once.
Result:	Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals.

storage

Store at -20°C

References

[1] Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. DOI:10.1016/j.bmcl.2011.01.016
[2] Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61. DOI:10.1095/biolreprod44.3.561

Spectrum Detail

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