About:
The neurotransmitter dopamine is widely distributed in the central nervous system, brain tissue and body fluids of mammals, and its trace determination is of great significance for neurophysiology, exercise physiology, pathology, clinical medicine and disease diagnosis. Dopamine (DA) is one of the most important catecholamines and plays a key role in the central nervous system and the kidney system. Dysregulation of dopamine in the body can lead to diseases such as heart disease, schizophrenia and Parkinson's disease. Dopamine hydrochloride has good water solubility, can enhance myocardial contractility and increase blood output, and is widely used in shock syndrome caused by myocardial infarction, trauma, endotoxin sepsis, cardiac surgery, renal failure, congestive heart failure and so on.
Production method:
It's made by opening a ring of piperethylamine. Add piperiethylamine and phenol to reaction pot, cool, slowly add hydrochloric acid, heat up to 110℃ reflux 12-44h. When the reaction reaches the end point, cool slightly and stir well with water. Stand stratification and separate the phenolized layer. The water layer was extracted with isopropyl acetate, and the extracted water layer was evaporated under pressure (8.0kPa) to dry, then 1/2 amount of ethanol and hydrochloric acid were added, and heated to dissolve. Cooling, crystallization, filtration, filter cake washed with ethanol, dry, to get the finished product. The yield is 74%.
China
