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ChemicalBook Product Catalog DL-AP5

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DL-AP5 NEW

$42.00 5mg

$74.00 10mg

$167.00 25mg

Min. Order
Purity99.33%
Cas No76326-31-3
Supply Ability10g
Update time2025-11-10

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

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United States

United States

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Chemical Properties

Product Name	DL-AP5
CAS No	76326-31-3
EC-No
Min. Order
Purity	99.33%
Supply Ability	10g
Release date	2025/11/10

Product Introduction

Bioactivity

Name	DL-AP5
Description	DL-AP5 is the racemic form of a selective N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant effects.
In vivo	DL-AP5, a competitive NMDAR antagonist, on tramadol state-dependent memory.?A single-trial step-down passive avoidance task was used for the assessment of memory retrieval in adult male NMRI mice.?Post-training i.p. administration of an atypical μ-opioid receptor agonist, tramadol (2.5 and 5 mg/kg), dose-dependently induced impairment of memory retention.?Pre-test injection of tramadol (2.5 and 5 mg/kg) induced state-dependent retrieval of the memory acquired under post-training administration of tramadol (5 mg/kg) influence.?Pre-test intra-CA1 injection of NMDA (10-5 and 10-4 μg/mouse) 5 min before the administration of tramadol (5 mg/kg, i.p.) dose-dependently inhibited tramadol state-dependent memory.?Pre-test intra-CA1 injection of DL-AP5 (0.25 and 0.5 μg/mouse) reversed the memory impairment induced by post-training administration of tramadol (5 mg/kg).?Pre-test administration of DL-AP5 (0.25 and 0.5 μg/mouse) with an ineffective dose of tramadol (1.25 mg/kg) restored the retrieval and induced tramadol state-dependent memory.?It can be concluded that dorsal hippocampal NMDAR mechanisms play an important role in the modulation of tramadol state-dependent memory.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O : 10 mM, Sonication is recommended. DMSO : Insoluble
Keywords	Tonic pain \| Retina \| NMDA \| Ionotropic glutamate receptors \| Inhibitor \| Inhibition \| inhibit \| iGluR \| Ganglion cells \| DL-AP-5 \| DL-AP5 \| DLAP5 \| DL AP5 \| Antinociceptive activity \| 2-APV
Inhibitors Related	Urethane \| L-Glutamic acid \| L-Phenylalanine \| glycine \| Halothane \| Evans blue \| L-Glutamic acid monosodium salt \| D-Serine \| Linalool \| Memantine \| O-Phospho-L-serine \| Corticosterone
Related Compound Libraries	Target-Focused Phenotypic Screening Library \| Anti-Neurodegenerative Disease Compound Library \| Pain-Related Compound Library \| Bioactive Compound Library \| Neuronal Signaling Compound Library \| Antidepressant Compound Library \| Anti-Parkinson's Disease Compound Library \| Neurotransmitter Receptor Compound Library \| Inhibitor Library \| Neuroprotective Compound Library \| NO PAINS Compound Library \| Bioactive Compounds Library Max

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