| Name | Diphenyleneiodonium chloride |
| Description | Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity. |
| Cell Research | Whole-cell growth inhibition assays were used to screen and identify novel inhibitors. The hit compounds(Diphenyleneiodonium chloride) were tested for cytotoxicity against Vero cells to determine the selectivity index, and time-kill kinetics were determined against Mycobacterium fortuitum. The compound's ability to synergize with amikacin, ceftriaxone, ceftazidime and meropenem was determined using fractional inhibitory concentration indexes followed by its ability to decimate mycobacterial infections ex vivo[1]. |
| In vitro | Diphenyleneiodonium chloride (DPIC), an NADPH/NADH oxidase inhibitor, as possessing potent antimicrobial activity against non-tuberculous mycobacteria.?DPIC exhibited concentration-dependent bactericidal activity against M. fortuitum and synergized with amikacin, ceftriaxone, ceftazidime and meropenem[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 6 mg/mL (19.07 mM)
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| Keywords | NADPH Oxidase | Diphenyleneiodonium | inhibit | Reactive Oxygen Species | NOX | Diphenyleneiodonium Chloride | Diphenyleneiodonium chloride | TRP Channel | Transient receptor potential channels | Inhibitor |
| Inhibitors Related | Imeglimin hydrochloride | Acetylcysteine | L-Ascorbic acid | Metronidazole | Glucosamine | D-(+)-Glucono-1,5-lactone | Lycopene | Naringenin | Diallyl disulfide | Apocynin |
| Related Compound Libraries | Highly Selective Inhibitor Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
United States
