| Name | Deoxycorticosterone acetate |
| Description | Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid. |
| Kinase Assay | Kinase inhibition: The ability of compounds to inhibit ATR, ATM or DNAPK kinase activity istested using a radiometric-phosphate incorporation assay. A stock solution isprepared consisting of the appropriate buffer, kinase, and target peptide. To this isadded the compound of interest, at varying concentrations in DMSO to a final DMSO concentration of 7%. Assays are initiated by addition of an appropriate [γ-33P]ATP solution and incubated at 25 ℃. Assays are stopped, after the desired time course, by addition of phosphoric acid and ATP to a final concentration of 100 mM and 0.66 μM, respectively. Peptides are captured on a phosphocellulose membrane, prepared as per manufacturer's instructions, and washed six times with 200 μL of 100 mM phosphoric acid, prior to the addition of 100 μL of scintillation cocktail and scintillation counting on a 1450 Microbeta Liquid Scintillation Counter. Dose?response data are analyzed using GraphPad Prism software |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 3.72 mg/mL (10 mM), Sonication is recommended.
Ethanol : 6 mg/mL (16.1 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Deoxycorticosterone | 11-Deoxycorticosterone Acetate | Inhibitor | Cortexone Acetate | renal inflammation | Deoxycorticosterone Acetate | adrenocortin | unilateral nephrectomy | DOC | Mineralocorticoid Receptor | Endogenous Metabolite | Deoxycorticosterone acetate | DOC Acetate | 11-Deoxycorticosterone | fibrosis | Cortexone | aldosterone | precursor | glomerular injury and proteinuria | inhibit |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Vanillin | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oleic acid |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Natural Product Library for HTS | FDA-Approved Drug Library | GPCR Compound Library |
United States
