| 名称 | Deoxycorticosterone acetate |
| 描述 | Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid. |
| 激酶实验 | Kinase inhibition: The ability of compounds to inhibit ATR, ATM or DNAPK kinase activity istested using a radiometric-phosphate incorporation assay. A stock solution isprepared consisting of the appropriate buffer, kinase, and target peptide. To this isadded the compound of interest, at varying concentrations in DMSO to a final DMSO concentration of 7%. Assays are initiated by addition of an appropriate [γ-33P]ATP solution and incubated at 25 ℃. Assays are stopped, after the desired time course, by addition of phosphoric acid and ATP to a final concentration of 100 mM and 0.66 μM, respectively. Peptides are captured on a phosphocellulose membrane, prepared as per manufacturer's instructions, and washed six times with 200 μL of 100 mM phosphoric acid, prior to the addition of 100 μL of scintillation cocktail and scintillation counting on a 1450 Microbeta Liquid Scintillation Counter. Dose?response data are analyzed using GraphPad Prism software |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 3.72 mg/mL (10 mM), Sonication is recommended.
Ethanol : 6 mg/mL (16.1 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
|
| 关键字 | Deoxycorticosterone | 11-Deoxycorticosterone Acetate | Inhibitor | Cortexone Acetate | renal inflammation | Deoxycorticosterone Acetate | adrenocortin | unilateral nephrectomy | DOC | Mineralocorticoid Receptor | Endogenous Metabolite | Deoxycorticosterone acetate | DOC Acetate | 11-Deoxycorticosterone | fibrosis | Cortexone | aldosterone | precursor | glomerular injury and proteinuria | inhibit |
| 相关产品 | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Vanillin | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oleic acid |
| 相关库 | 神经退行性疾病化合物库 | 经典已知活性库 | 膜蛋白靶向化合物库 | 药物功能重定位化合物库 | 高通量筛选天然产物库 | FDA 上市药物库 | GPCR靶点分子库 |
United States
