Physiological activity 1. Prevention and treatment of obesity DHEA has a thyroid-like effect, which can inhibit food and fat intake and reduce fat accumulation. Oral small dose of DHEA sulfate can improve the quantity and distribution of body fat and reduce blood lipid. In addition, DS can act on mitochondrial respiratory apparatus, inhibit food and fat intake, and is related to DHEA against glucocorticoids, which can prevent and control obesity. 2. Anti-diabetic DHEA has the effects of improving glucose tolerance, increasing insulin level and anti-diabetes. 3. Anti-cortical diseases DHEA can enhance the activity of the endocrine system, reduce cortisol levels, and play a role in resisting various pathological processes. The symptoms of patients with systemic lupus erythematosus (SLE) improved greatly after taking DHEA, indicating that DHEA has a certain effect on the treatment of SLE. DHEA can help the human body to obtain cortical antibodies. The concentration of DHEA in plasma has a great relationship with various cortical diseases. The lower the concentration, the greater the risk of disease. 4. Anti-cancer DHEA has a certain effect on the prevention and inhibition of tumor growth. Firstly, the anti-carcinogenic effect of DHEA has been clinically found to be related to the reversal of breast cancer. Low levels of DHEA were associated with bladder and stomach cancer and were not associated with age. It has been proven that DHEA has a protective and synergistic effect when used to chemotherapy tumors, because DHEA has an inhibitory effect on 5 phosphoribose, and DHEA plays a role in inhibiting cancer by inhibiting excessive mitochondrial (NADPH) and 5-phosphoribose ester. DHEA can inhibit the growth of pancreatic cancer cells. It is speculated that the mechanism is that DHEA can inhibit the growth of pancreatic cancer cells by regulating the alternating change of plasma estrogen concentration. 5. Anti-aging effect when people are 25 to 30 years old, the DHEA content in the body is the highest, and after 30 years old, it will gradually decline by Chemicalbook, the annual decline rate is about 2%, and when people are 70 years old, the DHEA content in the body has dropped to less than 25% of its young age; At the same time, the incidence of geriatric diseases associated with the decline in DHEA also increased. The decline of GnRH gene expression function leads to aging. It is believed that DHEA can restore the activity of GnRH neurons and prevent or improve some diseases related to DHEA decline by stimulating GnRH biosynthesis. 6. Immune response DHEA can restore the damaged immune response and improve the immune function of T cells and B cells. DHEA plays an important role in enhancing the physiological activity of insulin-like growth factor (IGF-1), and is a potentially beneficial drug for the treatment of immune deficiency. 7. Effect on bone DHEA itself cannot directly and independently affect the growth and differentiation of human osteoblasts, but it can achieve the growth and differentiation of osteoblasts by affecting the changes of 1, 25-dihydroxyvitamin D3. The effect of DHEA on bone depends on the presence of sex hormone in bone cells and its endocrine effect on osteoblasts. 8. Protein metabolism DHEA is a protein assimilation hormone that promotes protein synthesis. According to Marrero et al., feeding mice with DHEA (0.45%) can increase liver weight, increase liver mitochondria induced by liver protein, and restore RNA and protein synthesis. 9. Other aspects DHEA has conducted extensive clinical research on the treatment of menopausal syndrome, scleroderma, coronary heart disease, gout, psoriasis, AIDS, etc. The study also found that the pathogenesis of tuberculosis cytoplasmic deformation was related to the concentration of adrenocortical hormone and antiadrenocortical hormone. The concentration of Cortisol /DHEA-S in fetal plasma is strongly associated with the duration of delivery
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