D-Biotin NEW

• MOLECULAR FORMULA :

• C10-H16-N2-O3-S

• MOLECULAR WEIGHT :

• 244.34

• WISWESSER LINE NOTATION :

• T55 BMVM GSTJ H4VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• DOSE :

• 200 mg/kg

• SEX/DURATION :

• female 14-15 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

• REFERENCE :

• JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19- 1973- Volume(issue)/page/year: 22,181,1976

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• DOSE :

• 100 mg/kg

• SEX/DURATION :

• male 1 day(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

• REFERENCE :

• CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 42,613,1973

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• DOSE :

• 200 mg/kg

• SEX/DURATION :

• female 1-2 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

• REFERENCE :

• JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19- 1973- Volume(issue)/page/year: 21,89,1975

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 17 mg/kg

• SEX/DURATION :

• female 1-17 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Maternal Effects - other effects

• REFERENCE :

• EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 52,149,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80381 No. of Facilities: 129 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 8306 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80381 No. of Facilities: 1674 (estimated) No. of Industries: 9 No. of Occupations: 41 No. of Employees: 46583 (estimated) No. of Female Employees: 22672 (estimated)