| CAS: | 456-59-7 |
| MF: | C17H24O3 |
| MW: | 276.37 |
| EINECS: | 207-271-6 |
| Product Categories: | Cosmetic Ingredients & Chemicals;CYCLOSPASMOL;456-59-7 |
| Mol File: | 456-59-7.mol |
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| CYCLANDELATE Chemical Properties |
| Melting point | 55.0-56.5° |
| Boiling point | bp14 192-194° |
| density | 1.0535 (rough estimate) |
| refractive index | 1.5490 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| Water Solubility | Insoluble in water |
| solubility | Chloroform (Slightly), Methanol (Slightly, Sonicated) |
| form | powder to crystal |
| pka | 12.13±0.20(Predicted) |
| color | White to Almost white |
| Merck | 14,2704 |
| EPA Substance Registry System | Benzeneacetic acid, .alpha.-hydroxy-, 3,3,5-trimethylcyclohexyl ester (456-59-7) |
| CYCLANDELATE Usage And Synthesis |
| Description | Almond (Amygdalus communis L) is a kind of nut from Xinjiang, China. Traditional Chinese medicine believes that almond can promote blood circulation to dispel blood stasis, lubricate bowels to relieve constipation, and relieve cough and asthma. The indications include amenorrhea, fever, wind arthralgia, malaria, blood stasis and pain, injuries, and blood stasis with constipation. |
| Physical properties | Appearance: white or almost white amorphous powder, special smell, and bitter taste. Solubility: very soluble in ethanol or acetone and almost insoluble in water. Melting point: 50–62 °C. |
| Originator | Cyclospasmol,Ives,US,1958 |
| History | The chemical synthesis of cyclandelate was first synthesized by Funcke et al. from Elan Corporation in Ireland using a-hydroxyphenylacetic acid and cis-3,3,5-cycloalkyl cyclohexanol. The raw material of mandelic acid was obtained by hydrolysis after benzaldehyde reacted to sodium cyanide. However, sodium cyanide is hypertoxic, and because of its unique structure of a-hydroxy acid, it is easy to decompose under the acid condition, which leads to more by-products and low yield. A series of improved methods have been developed, which can reduce the environmental pollution under the premise of ensuring the yield of Zn/HCOONH4/ C2H5OH system . The method was used to synthesize cyclandelate since then. However, this drug has not yet been approved by the Food and Drug Administration in the United States, Canada, and other countries because it easily causes white blood cell deficiency. It has been withdrawn from the market after drug approval in Japan, France, and other countries in the 1970s. |
| Uses | vasodilator |
| Definition | ChEBI: The ester obtained by formal condensation of mandelic acid and 3,3,5-tricyclohexanol. It is a direct-acting smooth muscle relaxant used to dilate blood vessels. |
| Indications | The indications of cyclandelate are arteriosclerosis obliterans, acrocyanosis, cerebral arteriosclerosis, cerebral insufficiency, cerebrovascular disease, brain trauma, and post-traumatic brain syndrome. |
Product picture
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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