Name | COR659 |
Description | COR659 is a 2-acylaminothiophene derivative able to suppress alcohol and chocolate self-administration in rats, likely via positive allosteric modulation of the GABAB receptor and antagonism/inverse agonism at the cannabinoid CB1 receptor. |
In vitro | COR659 exerts its effects through a composite mechanism, including positive allosteric modulation of the GABAB receptor and action at the cannabinoid CB1 receptor [3]. |
In vivo | COR659 (0, 2.5, 5, and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats[1]. However, COR659 suppresses lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats[2]. Animal Model: Male sP and Wistar rats[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 33.33 mg/mL (98.66 mM)
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Keywords | Gamma-aminobutyric acid Receptor | sucrose | inhibit | chocolate | γ-Aminobutyric acid Receptor | COR 659 | GABA Receptor | Inhibitor | COR659 | COR-659 | alcohol |
Inhibitors Related | Valproic acid sodium salt | DL-Menthol | β-Caryophyllene | Penicillin G sodium salt | Halothane | Pregnenolone acetate | Valproic Acid | Chlorothymol | Piperazine citrate | Riluzole | 2,3-Butanediol | (-)-α-Pinene |
Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neuroprotective Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |