Clotrimazole

Standard: UPS43

Melting point :147-149°C

Boiling point: 501.14°C

Density: 1.1095

Refractive index: 1.5940

Storage conditions: 2-8°C

Solubility: Soluble in chloroform, DMSO, DMF and alcohols

Acidity coefficient (pKa): pKa 4.7(EtOH 50%aq ) (Uncertain)

(Predicted) Form :neat

Color: White 

Water solubility: <10mg/L(25 ºC)

Maximum wavelength (λmax): 556nm(Phosphate buffer sol.)(lit.)

Merck: 14,2417

Uses: Antifungal, used to treat epidermal and deep fungal infections, etc.

Production method : It is obtained by esterification, addition, hydrolysis, chlorination and condensation of o-chlorobenzoic acid. It can also be obtained by chlorination of o-chlorotoluene to obtain o-chlorotrichlorotoluene, which is then condensed with benzene in the presence of aluminum trichloride to generate diphenyl-(2-chlorophenyl)chloromethane, and finally condensed with imidazole to obtain clotrimazole.