Cloperastine hydrochloride

Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with an IC 50 value of 27 nM.Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.

Intheanesthetizedguineapigs,Cloperastineatatherapeuticdoseof1mg/kgprolongedtheQTintervalandmonophasicactionpotential(MAP)durationwithoutaffectingPRintervalorQRSwidth.CloperastinehydrochlorideshowsrelativelylowacutetoxicChemicalbookitywhenadministeredbytheintraperitonealrouteinratsandmice,andshowsminortoxicitybytheoralroutewhenadministeredasCloperastinefendizoate,theLD50inratsandmiceforthetwoadministrationroutesexceeds1000and2000mg/kg,respectively.

Brand: Soarwin

CAS No.:14984-68-0

EC Number:239-067-8

Molecular Formula: C20H25Cl2NO

Melting point:147.9°