Chlortalidone Impurity; 955-16-8
WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
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Product Code: C138003
English Name: Chlortalidone Impurity 3
English Alias: 5-phenylisobenzofuran-1,3-dione
CAS No.：955-16-8
Molecular Formula: C₁₄H₈O₃
Molecular Weight: 224.21
Purity Assurance: HPLC ≥99.5%, confirmed by IR and melting point analysis.
Stability: Shelf life of 36 months at room temperature, with <0.1% degradation in ethyl acetate.
Regulatory Compliance: Meets ICH Q3A for organic impurities in diuretics.
Residual Impurity Control: Detects benzofuranone in Chlortalidone via GC-MS.
Process Optimization: Monitors decarboxylation side reactions during synthesis.
Method Validation: Validates GC methods for volatile impurities.
This impurity originates from thermal degradation or cyclization of benzoic acid intermediates. It requires control due to potential genotoxicity concerns.
Detection: GC-MS with DB-5 column; LOD: 1 ppm.
Formation: Induced by high-temperature reaction steps; reducing reaction temperature lowers content by 80%.
Toxicity: Ames test shows no mutagenicity; further genotoxicity studies ongoing.
NOTE！
We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!
WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
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