Chlortalidone Impurity; 5543-24-8
WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
Product Code: C138001
English Name: Chlortalidone Impurity 1
English Alias: 2-(2-chlorobenzoyl)benzoic acid
CAS No.：5543-24-8
Molecular Formula: C₁₄H₉ClO₃
Molecular Weight: 260.67
High Purity: HPLC ≥99.0%, confirmed by NMR (1H, 13C) and HRMS, ensuring accuracy for impurity analysis.
Stability: Shelf life of 24 months at 2-8℃ in dark, with <0.5% degradation in DMSO within 1 month.
Regulatory Compliance: Meets ICH/FDA standards for pharmaceutical impurity control.
Quality Control: Detects Impurity 1 in Chlortalidone API via HPLC/LC-MS, ensuring ≤0.1% limit (ICH Q3A).
Process Optimization: Monitors chlorobenzoylation side reactions during synthesis to adjust reaction conditions.
Method Validation: Serves as a reference standard for analytical method development.
Chlortalidone, a thiazide-like diuretic, may generate this impurity from incomplete condensation or chlorination side reactions. Strict impurity control is essential for drug safety and efficacy.
Detection: UPLC-MS/MS with C18 column (1.7μm) achieves LOD of 0.01 ng/mL.
Formation: Arises from excess 2-chlorobenzoyl chloride; optimized stoichiometry reduces content by 70%.
Toxicity: In vitro studies show low cytotoxicity; ongoing safety evaluations pending.
NOTE！
We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!
WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
NEW IN STOCK!
The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery!
China
