Manufacturer Provide Raw Material CAS56-75-7 Chloramphenicol with Reasonable Price
Introduction
1.Product Name:Chloramphenicol
2.Other Name:chlornitromycin
3..CAS NO:56-75-7
4.Purity: 99%min
5.Appearance:White Liquid
6.Molecular formula: C11H12Cl2N2O5
7.Molecular weight:323.13
8.Melting Point :148-150 °C(lit.)
9.Boiling Point :644.9±55.0 °C
10.Density :1.6682 g/mL at 20 °C
11.Storage:Keep in dark place,Inert atmosphere,Room temperature
Chloramphenicol is a broad-spectrum antibiotic.Target: AntibacterialChloramphenicol is a bacteriostatic drug that stops bacterial growth by inhibiting protein synthesis. Chloramphenicol prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. It specifically binds to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit, preventing peptide bond formation. While chloramphenicol and the macrolide class of antibiotics both interact with ribosomes, chloramphenicol is not a macrolide. It directly interferes with substrate binding, whereas macrolides sterically block the progression of the growing peptide
Chloramphenicol, also known as chlornitromycin, is a broad-spectrum, bacteriostatic antibiotic derived from Streptomyces venezuelae. It is first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. The synthetic product is racemic, also called synthomycin. Syntomycin is a mixture of chloramphenicol L-isomer and d-isomer. Because of dextroisomer antibacterial effect, the effect of synthomycin is only half of the natural products. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It is effective against several gram-positive and gram-negative bacteria and commonly used in researching protein synthesis and to select for chloramphenicol-resistant transformed cells or the bacterial CAT gene.
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