| 体外活性 | Chitosans are recognized as versatile biomaterials because of their non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan is reported to have other biological properties, such as antitumor, antimicrobial, and antioxidant activities. It can be used in water treatment, wound-healing materials, pharmaceutical excipient or drug carrier, obesity treatment and as a scaffold for tissue engineering[1]. Antimicrobial activity of chitosan has been demonstrated against many bacteria, filamentous fungi and yeasts. Chitosan has wide spectrum of activity and high killing rate against Gram-positive and Gram-negative bacteria, but lower toxicity toward mammalian cells[2]. Chitosan exhibits antitumor activity against different types of cancer. For example, chitosan decreases adhesion of primary melanoma A375 cell line and decreases proliferation of primary melanoma SKMEL28 cell line, it has potent pro-apoptotic effects against RPMI7951, a metastatic melanoma cell line[3]. Chitosan and its derivatives act as antioxidants by scavenging oxygen radicals such as hydroxyl, superoxide, alkyl as well as highly stable DPPH radicals in vitro[4]. |
United States
