| Name | Cefoselis Sulfate |
| Description | Cefoselis Sulfate is a widely used beta-lactam antibiotic. |
| In vitro | Cefoselis inhibits GABA-induced currents in a concentration-dependent manner with IC50 of 185 mM. [1] Cefoselis possesses a superior antistaphylococcal activity on MSSA isolates to both other compounds being however equal active to Cefepime and Cefpirome on multiresistant enterobacteriaceae. [2] Cefoselis is dose-dependently appeared in brain extracellular fluid in proportion to its blood level. [3] Cefoselis, a new parenteral cephalosporin, is active against clinical isolates of both gram-positive and gram-negative aerobic bacteria. [4] |
| In vivo | Cefoselis elicits a massive elevation of extracellular glutamate concentration in normal rats. [3] Cefoselis (50 mg/animal)-induced convulsions are prevented by pretreatment with 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), diazepam and phenobarbital (ED(50) values (mg/kg) of 0.78, 1.59 and 33.0, respectively), but not by carbamazepine or phenytoin. [5] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 27.5 mg/mL (44.31 mM)
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| Keywords | Cefoselis | cephalosporin | Gram-negative | Gram-positive | Bacterial | FK 037 | barrier | FK037 | FK037 Sulfate | Inhibitor | Antibiotic | Cefoselis Sulfate | β-lactam | organisms | blood-brain | FK-037 Sulfate | inhibit |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | G-418 disulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | EDTA copper(II) disodium salt | Dimethyl sulfoxide | Crystal Violet |
| Related Compound Libraries | Bioactive Compound Library | Approved Drug Library | Drug Repurposing Compound Library | Beta-Lactam Compound Library | CNS-Penetrant Compound Library | NO PAINS Compound Library | Anti-Bacterial Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-Infection Compound Library |
United States
