| Name | Cefixime |
| Description | Cefixime (FR-17027) is a broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins. |
| Cell Research | The morphological changes of serovar Typhimurium FP39 in THP-1 cells are studied by light microscopy and transmission electron microscopy. Infected THP-1 cells are treated for 4 h with 0.5 μg of cefixime/ml. (Only for Reference) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : < 10 mg/mL (22.05 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
Ethanol : hardly dissolve
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (22.05 mM), Solution.
H2O : Insoluble
DMSO : 166.7 mg/mL (367.63 mM), Sonication is recommended.
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| Keywords | PBPs | Inhibitor | inhibit | FR17027 | FR 17027 | FK027 | FK 027 | CL284635 | CL 284635 | Cefixime | Bacterial | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | ReFRAME Related Library | Drug Repurposing Compound Library | Inhibitor Library | NO PAINS Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-Infection Compound Library | NMPA-Approved Drug Library |
United States
