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ChemicalBook Product Catalog C29

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C29 NEW

$47.00 1mg

$98.00 5mg

$189.00 10mg

Min. Order
Purity96.34%
Cas No363600-92-4
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	C29
CAS No	363600-92-4
EC-No
Min. Order
Purity	96.34%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	C29
Description	C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.
In vitro	C29 blunts hTLR2/1 and hTLR2/6 signaling in HEK-TLR2 Stable transfectants and THP-1 Cells. C29 blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 also inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation, as well as both P3C- and P2C-induced NF-κB–luciferase activity in transiently transfected HEK293T cells expressing hTLR2 and an NF-κB–sensitive luciferase reporter construct. C29 preferentially inhibits TLR2/1 signaling in primary murine macrophages. C29 blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 Cells and murine macrophages. C29 inhibits ligand-induced interaction of TLR2 with MyD88 and blocks MAPK and NF-κB activation[1].
In vivo	C29L inhibits TLR2/1-induced inflammation in mice. Mice treated twice with C29L before administration of P3C significantly blocks IL-12 p40 and TNF-α liver cytokine mRNA and serum protein. C29L has a significant inhibitory effect at the later time point for IL-12 p40[1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : Insoluble DMSO : 60 mg/mL (210.3 mM)
Keywords	TLR2 \| Inhibitor \| hTLR2/1 \| inhibit \| C-29 \| Toll-like \| C 29 \| Toll-like Receptor (TLR) \| hTLR2/6 \| C29
Inhibitors Related	Polyinosinic-polycytidylic acid sodium \| CU-CPD107 \| Imiquimod hydrochloride \| Hydroxychloroquine \| Chloroquine phosphate \| Hydroxychloroquine sulfate \| Chloranil \| Chloroquine \| CU-115 \| Imiquimod \| TLR3-IN-1 \| Resiquimod
Related Compound Libraries	Nonsteroidal Anti-Inflammatory Compound Library \| Anti-Neurodegenerative Disease Compound Library \| Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| HIF-1 Signaling Pathway Compound Library \| Pyroptosis Compound Library \| Inhibitor Library \| NO PAINS Compound Library \| Bioactive Compounds Library Max \| Anti-Infection Compound Library

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