Full Name：Body Protecting Compound-157/BPC 157
CAS:137525-51-0
Molecular Formula:C₆₂H₉₈N₁₆O₂₂
Molecular Weight:1419.55 g/mol
Sequence (Amino Acids):Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (15-mer peptide)
Source:Synthetic peptide derived from human gastric juice protein
Solubility:Soluble in water (>5 mg/mL)
Stability:Stable at room temperature (short-term); recommended storage at -20°C for long-term
Biological Role:- Promotes tissue healing (tendons, muscles, gut)
- Anti-inflammatory effects
- Angiogenesis stimulation
- Cytoprotective properties
Mechanism of Action:Modulates growth factors (e.g., VEGF, FGF), nitric oxide (NO) pathways, and inflammatory cytokines
Half-life:Not fully established (likely short; minutes to hours)
Note:Not FDA-approved; primarily used in preclinical research
| Test Parameter | Specification | Method | Acceptance Criteria | Results (Example) |
|---|
| Appearance | White to off-white powder | Visual inspection | Free-flowing, homogeneous | Complies |
| Identification | BPC-157 (Sequence Verification) | HPLC-MS / Amino Acid Analysis | ≥ 98% Match to reference | 99.2% |
| Purity (HPLC) | Chromatographic purity | RP-HPLC (UV 220 nm) | ≥ 98% | 98.7% |
| Water Content | Residual moisture | Karl Fischer Titration | ≤ 5.0% (w/w) | 3.2% |
| Acetate Content | Counterion quantification | Ion Chromatography | ≤ 10.0% (w/w) | 6.5% |
| Peptide Content | Net peptide mass | Amino Acid Analysis | ≥ 80% (lyophilized powder) | 85.3% |
| Solubility | Clear solution at 1 mg/mL in water | Visual (aqueous solution) | No precipitates | Complies |
| pH (1% Solution) | pH range | pH meter | 5.0–7.5 | 6.1 |
| Heavy Metals | Pb, Cd, Hg, As | ICP-MS | ≤ 10 ppm total | <5 ppm |
| Microbial Limits | Total viable count | USP <61> | ≤ 100 CFU/g | <10 CFU/g |
| Endotoxins | Bacterial endotoxins | LAL Test | ≤ 10 EU/mg | <5 EU/mg |
| Sterility (if sterile) | Microbial growth | USP <71> | No growth in 14 days | Complies |
China
