| Name | Benzethonium chloride |
| Description | Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties. |
| Cell Research | Cells are seeded in 96-well plates at 5,000 per well in 100 μL of growth medium and allowed to incubate for 24 hours. Benzethonium chloride is then added, as indicated, in a total volume of 5 μL. After 48 hours, MTS assay is done according to the specifications of the manufacturer, with DMSO (0.1%)–treated cells as negative control and cisplatin (166.6 μM)–treated cells as positive control.(Only for Reference) |
| In vitro | Administered in SCID mice bearing human laryngeal squamous cell carcinoma tumors, Benzethonium chloride (5 mg/kg) inhibited the growth of xenografts. |
| In vivo | In human hypopharyngeal squamous carcinoma cells, Benzethonium chloride at a concentration of 9 µM induces apoptosis and activates caspases after 12 hours. Furthermore, Benzethonium chloride at 5 µM enhances the effect of glucose consumption on the intracellular solute Ca(2+) concentration and its binding to membrane-associated proteins. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (100.43 mM)
H2O : 83 mg/mL (185.2 mM)
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| Keywords | Nicotinic acetylcholine receptors | Inhibitor | Benzethonium chloride | Benzethonium | nAChR | inhibit | Benzethonium Chloride |
| Inhibitors Related | Adiphenine hydrochloride | Nanofin | Arecoline hydrobromide | Forskolin | CLOZAPINE N-OXIDE | Pilocarpine nitrate | Ribavirin | Adenine | Choline chloride | Propoxur |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Drug Repurposing Compound Library | NO PAINS Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max |
United States
