| 名称 | Cetylpyridinium Chloride |
| 描述 | Cetylpyridinium Chloride (Hexadecylpyridinium Chloride) is a cationic quaternary ammonium compound used as oropharyngeal antiseptic. |
| 体外活性 | Cetylpyridinium chloride (CPC) as active ingredient of antiseptic oral mouthrinses has a broad antimicrobial spectrum with a rapid bactericidal effect on gram-positive pathogens and a fungicide effect on yeasts in particular. Application of CPC at a concentration of 0.05% as a mouthrinse results in an immediate reduction in bacterial counts of 2.0 to 2.5 log steps (which is adequate to > 99%). This reverts to about 1 log step (= 90%) 1 h after application. The ability of CPC to inhibit plaque and thereby reduce gingivitis is assured. In comparison to chlorhexidine, CPC has a lower residual effect, and as a result a lesser effect against plaque and gingivitis. The efficacy of CPC against oropharyngeal candidiasis is assured. CPC mouthrinses can significantly reduce infectious aerosols in dental practice, thereby protecting both staff and the patient. The balance of intra-oral bacterial flora is not disturbed even in the case of relatively long-term use of CPC (up to six weeks). [1] |
| 体内活性 | Cetylpyridinium chloride increases the risk of severe allergic reactions, such as swelling of the mouth, face, lips or tongue, labored breathing, rashes, and hives. Ingesting high concentrations of cetylpyridinium chloride can lead to lung damage. Cetylpyridinium chloride is toxic if swallowed or inhaled. [2] |
| 存储条件 | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 62 mg/mL (182.4 mM)
Ethanol : 63 mg/mL (185.3 mM)
DMSO : 45 mg/mL (132.36 mM), Sonication is recommended.
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| 关键字 | Cetylpyridinium | Cetylpyridinium Chloride | HBV | assembly | quaternary | Inhibitor | anti-bacterial | ammonium | inhibit | mouthwashes | cationic | Hepatitis B virus | replication | Capsid | pesticides | Bacterial |
| 相关产品 | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Doxycycline (hyclate) | Kanamycin sulfate | G-418 disulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Dimethyl sulfoxide | Crystal Violet |
| 相关库 | FDA上市及药典收录分子库 | 经典已知活性库 | 药物功能重定位化合物库 | 抗病毒库 | NO PAINS 化合物库 | 抗菌活性库 | 化妆品成分化合物库 | 已知活性化合物库 | 临床前化合物库 | 抗感染化合物库 |
United States
