| CAS: | 55-48-1 |
| MF: | 2C17H23NO3.H2O4S |
| MW: | 676.82 |
| EINECS: | 200-235-0 |
| Product Categories: | Alkaloids;55-48-1 |
| Mol File: | 55-48-1.mol |
 |
|
| Atropine sulfate Chemical Properties |
| Melting point | 189-192 °C (A)(lit.) |
| Boiling point | 135 °C |
| density | 1.1172 (rough estimate) |
| refractive index | 1.6900 (estimate) |
| storage temp. | 0-6°C |
| solubility | Soluble in DMSO |
| color | Crystals |
| CAS DataBase Reference | 55-48-1(CAS DataBase Reference) |
| EPA Substance Registry System | Atropine sulfate (55-48-1) |
| Atropine sulfate Usage And Synthesis |
| Uses | anticholinergic agent |
| Uses | cholinergic receptor antagonist |
| Brand name | Atrophate [Veterinary] (Schering-Plough Animal Health); Atropisol (Ciba Vision, US Ophthalmics); Isopto Atropine (Alcon). |
| General Description | Atropine sulfate (Atropisol)is prepared by neutralizing atropine in acetone or ethersolution with an alcoholic solution of sulfuric acid, withcare used to prevent hydrolysis. The salt occurs as colorlesscrystals or as a white, crystalline powder. It is efflorescentin dry air and should be protected from light to preventdecomposition.
Atropine sulfate is freely soluble in water (1:0.5), in alcohol(1:5, 1:2.5 at boiling point), and in glycerin (1:2.5).Aqueous solutions are not very stable, although solutionsmay be sterilized at 120°C (15 lb pressure) in an autoclave if the pH is kept below 6. Sterilization probably is besteffected by the use of aseptic techniques and a bacteriologicalfilter. It has been suggested that no more than a 30-daysupply of an aqueous solution should be made and that forsmall quantities the best procedure is to use hypodermictablets and sterile distilled water. Kondritzer andZvirblis have studied the kinetics of alkaline and protoncatalyzedhydrolyses of atropine in aqueous solution. Theregion of maximal stability lies between pH 3 and approximately5. They have also proposed an equation to predictthe half-life of atropine undergoing hydrolysis at constantpH and temperature. |
| Clinical Use | Atropine may be used to treat some types of arrhythmias. Itincreases the heart rate by blocking the effects of ACh on thevagus. In this context, it is used to treat certain reversible bradyarrhythmiasthat may accompany acute myocardial infarction.It is also used as an adjunct to anesthesia to protect againstbradycardia, hypotension, and even cardiac arrest induced bythe skeletal muscle relaxant succinylcholine chloride.
Another use for atropine sulfate emerged following thedevelopment of the organophosphates, which are potent inhibitorsof AChE. Atropine is a specific antidote to preventthe muscarinic effects of ACh accumulation, such as vomiting,abdominal cramps, diarrhea, salivation, sweating, bronchoconstriction,and excessive bronchial secretions. It isused intravenously but does not protect against respiratoryfailure caused by depression of the respiratory center andthe muscles of respiration. |
| Safety Profile | Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human (child) pulmonary system effects by ingestion. Human systemic effects: decreased body temperature, cardiac arrhythmias. An experimental teratogen. Other experimental reproductive effects. See also ATROPINE. When heated to decomposition it emits very toxic fumes of NO,xand SOx. |
| Veterinary Drugs and Treatments | The principal veterinary indications for systemic atropine include:
!!Preanesthetic to prevent or reduce secretions of the respiratory tract
!!Treat sinus bradycardia, sinoatrial arrest, and incomplete AV block
!!Differentiate vagally-mediated bradycardia for other causes
!!As an antidote for overdoses of cholinergic agents (e.g., physostigmine, etc.)
!!As an antidote for organophosphate, carbamate, muscarinic mushroom, blue-green algae intoxication
!!Hypersialism
!!Treatment of bronchoconstrictive disease |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Contact Information
1. Shanghai Affida New Technology Center, located in Fengxian District, Shanghai. The company produces more than 1000 kinds of high-quality products I20 production lines to provide OEM services, as one of the most dynamic industry and trade integrated companies in the Chinese market.
2, our advantage comes from our service, we can provide fast delivery. The average delivery time in peak season is less than 15 working days, and the average delivery time in off-season is less than 1 month. We have successfully transported many chemical raw materials to many countries in the world. Good feedback and repeat orders have supported the growth of our company.
3, independent production lines, we have 20 pharmaceutical raw materials, organic solvents and other raw material production lines. In addition, we also have an API production workshop with independent research and development production lines, as well as an API research and development testing center. We can provide you with sample testing and accept small orders. Supply 99%+ quality chemical products.
4. We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Ouda will be your strong, sincere and reliable partner in China.
Advantages:
1. Samples are provided for test;
2. Good quality products;
3. 100% secure delivery.
4. secure your money, lower the risk
5.Payment ways: Western Union, Moneygram, Bitcoin, T/T，USDT、PAYPAL
6.Delivery: EMS/ EUB/ USPS/ UPS/ TNT/ FEDEX/ DHL /DPDetc
7.Packaging:safe and discreet packaging
Our company Superiority
1 Best service, high quality and reasonable price
2. It's customers' right to choose the package (EMS, DHL, FedEx, UPS);
3. It's customers' right to choose the packing way for his products from many recent effective packing ways
4. Specials are possible when client's order is big enough, including the discount policy;
5.Our company promise to deliver clients' package to his hands safely, or we'll cover the total loss and reship in time;
Our company supply high quality chemical products with the most competitive prices.
If have any need or question, contact us freely.
Hope we can have chances to build good long-term cooperation.
Inquiry guide
1. Please send the quantity(Weight) to us, we will arrange our sales to provide the one-for-one service for you.
2.Then we will provide the professional quotation list for you, it will be including all the factors in whole business process(Quality, shipping, payment, files etc.).
3.If you have many products need inquiry, please send the list for us, the product clear information includes CAS + Name + quantity(Weight), we will provide the complete solution for you. We also provide the customization product.
WhatsApp:+13106542038
Email: jan@oudaxin.com
China
