| Name | Astragalus polysaccharide |
| Description | Astragalus polysaccharide, a natural product derived from Astragalus propinquus, exhibits anticancer activity and has been shown to be effective in hepatocellular carcinoma (HCC) by inhibiting the M2 polarization of tumor-associated macrophages (TAM). |
| In vitro | Astragalus polysaccharide (APS) (100 μg/mL; PBMCs) induced mature DCs could stimulate the proliferation of allogeneic T lymphocytes. The proliferation index of T cells increased with an increased ratio of stimulator cells to effector cells (P < 0.05). Levels of IL-12 and IFN-gamma in the co-culture supernatant significantly increased in a time-dependent manner (P < 0.05). APS could in vitro induce DCs to mature, promote its antigen-presenting capacity, effectively activate CTLs, and enhance the anti-tumor function of the organism.[2] |
| In vivo | Astragalus polysaccharide (APS) (20 mg/kg; intragastric; once daily; 10 weeks; diabetes-induced SD rats) administration decreased the rats' fasting plasma glucose (FPG) levels and body weight. APS (20 mg/kg) administration improved the cognitive performance of diabetes-induced rats in the Morris water maze test. APS (20 mg/kg) administration reduced the number of dead cells in the CA1 region of the hippocampus. Furthermore, APS (20 mg/kg) administration obviously upregulated the phosphorylation levels CREB, NMDA, and CaMK II. CONCLUSIONS These results suggest that APS has neuroprotective effects, and it may be a candidate for the treatment of neurodegenerative diseases such as diabetic cognitive impairment.[1] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 31.25 mg/mL, Sonication is recommended.
DMSO : 50 mg/mL, Sonication is recommended.
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| Keywords | TAMReceptor | TAM Receptor | TAM | 89250-26-0 |
| Inhibitors Related | Cabozantinib | UNC2025 | Gilteritinib | Bemcentinib | Dubermatinib | Sitravatinib | NCT-503 | Tepotinib | Cabozantinib S-malate | AXL-IN-13 | G-749 | BMS 777607 |
United States
