ARG-GLY-ASP NEW

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Min. Order1KG
Purity99%
Cas No99896-85-2
Supply Ability1T
Update time2025-10-22

Shandong Hanjiang Chemical Co., Ltd

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Chemical Properties

Product Name	ARG-GLY-ASP
CAS No	99896-85-2
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	1T
Release date	2025/10/22

Product Name:	ARG-GLY-ASP
Synonyms:	H2N-RGD-OH;H-ARG-GLY-ASP-OH;L-ARG-GLY-ASP;ARGINYL-GLYCYL-ASPARTIC ACID;ARG-GLY-ASP;ARG-GLY-ASP PEPTIDE;Arg-Gly-Asp acetate;Arginyl-glycyl-asparagilin
CAS:	99896-85-2
MF:	C12H22N6O6
MW:	346.34
EINECS:
Product Categories:	Peptide;Cell Signaling Enzymes;ECM ProteinsCytoskeleton and Extracellular Matrix;Extracellular Matrix;Extracellular Matrix Peptides (ECM);Extracellular Matrix Peptides and ProteinsPeptides for Cell Biology;Fibronectin Fragments and Analogs;Matrix Metalloproteinases Products;Various Peptides
Mol File:	99896-85-2.mol

ARG-GLY-ASP Chemical Properties

Melting point	153-155℃ (ethyl ether )
density	1.61±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in 0.1N acetic acid at 20mg/ml
pka	2.85±0.10(Predicted)
form	Powder
color	White to off-white
biological source	synthetic
Water Solubility	Soluble to 12 mg/mL (34.64 mM) in Water
Sequence	Arg-Gly-Asp
InChIKey	IYMAXBFPHPZYIK-BQBZGAKWSA-N
SMILES	C(O)(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)N

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

ARG-GLY-ASP Usage And Synthesis

Chemical Properties	White to off-white powder
Uses	Arg-Gly-Asp has been used: to saturate the cell surface Arg-Gly-Asp (RGD) receptors and inhibit marrow stromal cell (MSC) attachment to peptide modified hydrogel in adhesion assay in inhibition assay to confirm the β1-integrin-dependency of cell adhesion in textile fabrication and RGD textile functionalization to engineer a population of human dermal fibroblasts with impaired migration to modify glass substrate and evaluate the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs) in the cell culture of human mammary epithelial cells
Definition	ChEBI: Arg-Gly-Asp is an oligopeptide.
General Description	Arg-Gly-Asp (RGD) is an integrin binding site, which belongs to the class of adhesive proteins. It functions as a brain tumor targeting ligand.
Biological Activity	synthetic peptides containing the arginine-glycine-aspartate (rgd) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the rgd motif is an integrin-recognition motif found in many ligands.
Biochem/physiol Actions	Primary sequence involved with the binding of proteins to cell surfaces
in vitro	rgd peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. previous study demonstrates that rgd peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].
in vivo	anima study suggested that the rgd-4c-fitc-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].
target	integrin-ligand interaction
storage	Store at -20°C
references	[1] nature. 1999 feb 11;397(6719):534-9.rgd peptides induce apoptosis by direct caspase-3 activation. buckley cd1, pilling d, henriquez nv, parsonage g, threlfall k, scheel-toellner d, simmons dl, akbar an, lord jm, salmon m. [2] cancer res. 2002 sep 15;62(18):5139-43. arginine-glycine-aspartic acid (rgd)-peptide binds to both tumor and tumor-endothelial cells in vivo. zitzmann s1, ehemann v, schwab m.

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