Ambroxol hydrochloride NEW

Ambroxol Hydrochloride (AmbroxolHydrochloride) is also known as bromocyclohexylamine hydrochloride, and its chemical name is trans-4-[(2-amino3,5-dibromobenzyl)amino]cyclohexanol hydrochloride, which is The active metabolite of the sputum drug bromhexine (N-desmethyl, cyclohexyl is introduced into the trans-hydroxyl group at the para position), the toxicity is lower than that of bromhexine, and the activity is higher than that of bromhexine.

Application & Function

1. The effect of relieving cough and resolving phlegm:
Ambroxol hydrochloride mainly acts on secretory cells in the respiratory tract, regulates the secretion of mucus and serous substances, increases the secretion of serous, and can also lyse the polysaccharide fibers of acid glycoprotein in sputum, and inhibit the acidic protein in mucous glands and goblet cells. The synthesis of sputum reduces the viscosity of sputum, makes sputum thin and easy to discharge; at the same time, the drug can also increase the frequency and intensity of the movement of respiratory tract cilia, promote sputum discharge and self-purification of the respiratory tract.
2. Antioxidant effect:
Ambroxol hydrochloride has a significant antioxidant effect and plays an important role in the pathological changes of lung diseases caused by reactive free oxygen groups. Studies have shown that ambroxol has a strong inhibitory effect on H2O2 produced by neutrophils; in addition, ambroxol can also activate the intracellular glutathione system and promote intracellular glutathione (GSH) Synthesized to resist the damaging effects of oxygen free radicals.