| Name | Albendazole |
| Description | Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations. |
| In vitro | In sheep lambs administered Albendazole intravenously, the drug and its active metabolite, albendazole sulfoxide, are recovered in tapeworms. In rats, Albendazole significantly increases hepatic activity: it induces a 65-fold increase in CYP1A1-related ethoxyresorufin O-deethylase (EROD) activity, a 6-fold increase in CYP1A2-related methoxyresorufin O-demethylase activity, a 4-fold increase in CYP2B1-related pentoxyresorufin O-dealkylase activity, a 14-fold increase in CYP2B2-related benzyloxyresorufin O-dealkylase activity, and also leads to a partial reduction in CYP2E1-related p-nitrophenol hydroxylase activity. Albendazole is metabolized by liver and lung microsomes in sheep and cattle as well as bovine intestinal microsomes into its pharmacologically active sulfoxide metabolite. |
| In vivo | Albendazole and its sulfoxide metabolites induce the accumulation of cells in the mitotic phase. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 10 mg/mL (37.69 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Reactive Oxygen Species | HIF/HIF Prolyl-Hydroxylase | Inhibitor | LC3 | Echinococcus granulosus | caspase-3 | Hypoxia-inducible factors | VEGFR | Autophagy | inhibit | PARP | tapeworm | HIFs | Microtubule/Tubulin | VEGF | SKF 62979 | Parasite | SKF62979 | parasiticide | Apoptosis | HIF-PH | Vascular endothelial growth factor receptor | Albendazole |
| Inhibitors Related | Neomycin sulfate | Ampicillin sodium | Kanamycin sulfate | Sulfamethoxazole sodium | Hydroxychloroquine | Metronidazole | Doxycycline | Hydroxycitric acid tripotassium hydrate | EDTA copper(II) disodium salt |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Microtubule-Targeted Compound Library | Antiparasitic Natural Product Library | NO PAINS Compound Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
United States
