AICAR/ Acadesine

1. Aicar is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia.

2. Cardioprotective.Biological Activity Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

3. Aicar is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide. It can also be known as AICA ribonucleotide, ZMP, or Acadesine. It is an intermediate contained in the generation of inosine monophosphate. It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production. It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P.

Aicar Function:

1. Aicar is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).

2. Aicar can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion.

3. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.

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FAQ

 

Q: How to start orders or make payments?

A: You can send your requirement here on line,or send your purchase order by email to us, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

Q: How to confirm the Product Quality before placing orders?

A: You can buy samples for some products,and there will be discount for sample, after testing our sample, if all is ok for you, when make bulk order, we can return the sample fee back to you, and you can also send us your requirement for some special item, we can found for you in our local market.

Q: What's your MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 1kgs. For other low value product, our MOQ starts from 10kg and 100kg.

Q: Is there a discount?

A: Different quantity has different discount, for larger quantity, we alway support with better price.

Q: How to contact us? 

A: You can chat with us by Whatsapp & Skype & wechat Online. You can also choose your interested products and send inquiry to us. You can dial our telephone directly, you will get our reply. Send Email to us.
 

Company Profile

Hebei Ningnan Trade Co., Ltd. located in Shijiazhuang City, Hebei Province, is a large enterprise specializing in production and R & D. Our company has many years of export experience in this industry and professional logistics distribution.

We have many production lines, including industrial chemicals, pharmaceutical chemicals, chemical raw materials, fine chemicals and customized synthetic products.

We have a professional R & D team. Products are widely used in industry, rubber, textile, pharmaceutical and other industries. Products are exported to Europe, America, Southeast Asia and other countries. New and old customers are welcome to negotiate business.