| Name | AFMK |
| Description | AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine in PANC-1 cells. |
| In vitro | In PANC-1 cell, AFMK in combination with Gemcitabine increases the inhibition of the production of HSP70 from 0.47 (Gemcitabine alone) to 0.13 (10 nM AFMK), 0.08 (0.1 nM AFMK) and 0.01 (0.001 nM AFMK)[1]. AFMK pretreatment significantly inhibits DNA damage and shows a very high hydroxyl radical scavenging potential with an IC50 of 338.08 nM[3]. |
| In vivo | In male C57BL mice, AFMK (10 mg/kg; i.p.) significantly reverses radiation-induced decline in the total antioxidant capacity of plasma. Pretreatment of AFMK shows a significantly lower value of comet tail length and % DNA in tail[3]. |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (189.19 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.57 mM), Sonication is recommended.
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| Keywords | Human Endogenous Metabolite | Freeradicalscavengers | Free radical scavengers | EndogenousMetabolite | Endogenous Metabolite | Apoptosis | Antioxidant | AFMK |
| Inhibitors Related | Sucrose | Aceglutamide | L-Pyroglutamic acid | Emtricitabine | Levulinic acid | D(+)-Raffinose pentahydrate | D-(+)-Trehalose dihydrate | Glycerol | Thymidine | Gluconate Calcium | Chitosan oligosaccharide | 3-Indoleacetic acid |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Antioxidant Compound Library | Anti-Aging Compound Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Human Metabolite Library | Anti-Cancer Active Compound Library |
United States
